The crash happened at about 1:50 a.m. on Sunday, March 13, on I-84 Westbound near Entrance 56 ramp in East Hartford, according to Connecticut State Police.
While traveling at a high rate of speed, a 2014 Hyundai Santa Fe Sport struck a 2002 Toyota Carolla from behind, police said.
Authorities said the Hyundai rolled over and came to a rest on its roof in the left lane, and the Toyota spun out off the roadway and came to a rest on the shoulder.
The driver of the Toyota, identified as a 21-year-old woman from Chicopee, Massachusetts, was hospitalized with suspected serious injuries, police said.
Two passengers in the Toyota, a 24-year-old woman from Holyoke, Massachusetts, and a 26-year-old woman from Springfield, Massachusetts, were hospitalized with suspected minor injuries.
The driver of the Hyundai, a 23-year-old Hartford man, was also hospitalized with suspected minor injuries, police reported.
The two vehicles were towed from the scene, authorities said.
The investigation into the crash is ongoing.
Police asked witnesses and those with dashcams who were driving in the area at the time of the crash to contact Trooper Michael Dean at 860-534-6039 or at michael.dean@ct.gov.
Click here to follow Daily Voice Springfield and receive free news updates.